In 2016, nearly 59 million operations and medical procedures were conducted in German hospitals. According to a representative analysis, surgical site infections (SSI) accounted for 22.4% of nosocomial infections, exceeded only by lower respiratory infections. Considerable attention should be given to the prevention of SSI, as they can be associated with a 2 to 11-fold increase in a patient’s mortality rate. With the appropriate pre-, intra- and postoperative measures, however, up to 60% of all SSI can be prevented. On this factsheet you will find information on preoperative risk factors and prevention options.